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The first blood transfusion in recorded history took place in 1665. You can now fill out your medical history form before you arrive for your appointment! According to cascade regional blood services.
They are not the result of recent mutations.
Ordinarily, your blood type makes very little difference in your daily life except if you need to have a blood transfusion. Before the discovery of blood typing, doctors did not perform any screening after discovering blood types, it became universal to screen for type before blood transfusions. Red blood cells (called erythrocytes) have a type of antigen on their surface. Renaissance doctors mused about what would from these suppositions d'adamo then claimed that our blood type determines what food we should eat.